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Very poor/Comprehensive Metabolizers, CYP2D6 The development in the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Around 7% with the inhabitants has reduced action in the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These people are “weak metabolizers” of debrisoquine, dextromethorphan and tricycli

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